We investigate transcriptional and translational regulation in microorganisms, with the aim of uncovering the principles governing gene expression and translating these into predictive and engineering frameworks.
Our research is organised around three closely connected themes:
Gene regulation and predictive modelling
Transcriptional and translational regulation is studied in order to uncover the sequence and contextual principles that shape gene expression. This includes promoter architecture, σ-factor biology, and AI-driven sequence–function modelling.
Synthetic biology and biological design
Regulatory elements and gene expression systems are engineered using both mechanistic insight and data-driven models, with the aim of enabling controlled and predictable function across diverse microbial hosts.
High-throughput experimental systems
Experimental platforms are developed and applied for large-scale screening, single-cell analysis, and systematic sequence–function mapping, including microfluidic and other high-throughput approaches.
Our research spans a broad range of microbial systems, including model organisms, industrial hosts, photosynthetic microorganisms, actinomycetes, and extremophiles, in both environmental and biotechnological contexts.
Ongoing projects
International
- 2026 – 2030 - Horizon Europe, EU – AIMARIA, coming soon… Project coordinator (NTNU)
- 2026 – 2030 - Horizon Europe, MSCA Doctoral Networks, EU – MetaExplore, Ultrahigh-throughput exploration of metagenomic sequence space to discover and engineer novel biocatalysts and bioactive compounds. Project partner (NTNU | Syngens)
- 2025 – 2028 - Horizon Europe, EU – Sustainable exploration and biodiscovery of novel products and processes from extreme aquatic microbiomes to expedite the circular bioeconomy. Project partner (Syngens)
- 2024 – 2029 - U.S. National Science Foundation – Global Centers: CIRCLE Center for Innovative Recycling and Circular Economy. Project partner (Syngens)
- 2024 – 2026 - Innovation Fund Denmark-AgriFoodTure, Denmark – Enhancing Growth and Performance of Cultivated Muscle Cells through Targeted Hydrolysis (MuscleFuel). Project partner (NTNU | Syngens)
- 2023 – 2027 - Horizon Europe, EU – From solar energy to fuel: A holistic artificial photosynthesis platform for the production of viable solar fuels. Project partner (NTNU | Syngens)
- 2022 – 2026 - Horizon Europe, EU – Innovative Tools for Sustainable Exploration of Marine Microbiomes: Towards A Circular Blue Bioeconomy and Healthier Marine Environments. Project partner (NTNU)
National
- 2026 – 2031 - RCN - Quantum Centers, Norway – NorQSoft – Norwegian Quantum Software Center, led by Shaukat Ali (Simula Research Laboratory). Project partner (Syngens)
- 2026 – 2028 - RCN - Innovation Project for the Industrial Sector, Norway – Verification. Project leader (Syngens)
- 2026 – 2028 - RCN - KSP, Norway – THREADS -Textile Recycling by sustainable biotechnology-based approaches. Project partner
- 2025 – 2028 - RCN - Enabling Technologies, Norway – SafePhaeO3: Data-driven engineering of microalgal biofactories for safe and efficient omega-3 production. Project partner
Finalised projects
International
- 2018 – 2022 - H2020, EU – Conversion of forestry sugar residual streams to antimicrobial proteins by intelligent fermentation. Project partner
- 2017 – 2021 - EPSRC, UK – Design the Future 2: Thinking Soils: Engineered bacteria as computational agents in the design and manufacture of new materials and structures. Project partner
- 2016 – 2020 - H2020, EU – Advanced toolbox for rapid and cost-effective functional metagenomic screening – microbiology meets microfluidics. Project partner
National
- 2020 – 2025 - RCN-FRIPRO, Norway – An interdisciplinary data-driven approach to resolve sigma-factor-specific promoter dependency in bacteria (SiD). Project leader (NTNU)
- 2024 – 2025 - Digital Life Norway – Innovation Roadmap TA 1 - Value your data. Project leader (NTNU | Syngens)
- 2018 – 2021 - NTNU Enabling Technologies, Biotechnology – Miniaturised Droplet Biotechnology (iDrop). Ph.D. project, Co-PI
- 2017 – 2021 - NTNU Enabling Technologies, Biotechnology – A New Enabling Technology Platform for Recombinant Protein Production. Ph.D. project, PI
- 2019 – 2020 - FORNY2020, The Research Council of Norway – Fast-X-Press, Fast track for efficient protein production in novel hosts. Project leader
- 2018 – 2019 – NTNU Discovery, Main Project – SUPERAP for protein production at industrial scales. Project leader
- 2017 – 2018 - NTNU Discovery, Pilot Project – A key enabling expression platform. Project leader
- 2016 – 2017 - NTNU Biotechnology Program, Bluesky Microfinance Project – Protein Expression and Codon Restriction À-La-Carte. Co-PI
- 2016 – NTNU-AVIT - A university-wide distributed analytical robotic infrastructure. Co-PI
- 2012–2015 - BIOTEK2021, Research Council of Norway – Collaboration with US partners on bioprospecting in oil reservoirs and Arctic marine environments. Project leader (2014–2015)